Update: August 22, 2021 3:24 PM STI
Washington [US], Aug 22 (ANI): A new study by scientists at Salk has shown that time-limited eating (TRE), a diet that limits eating to specific times, has multiple health benefits in addition to weight loss. The study also shows that these benefits may depend on gender and age.
The results of the study were published in the journal “Cell Reports”.
Most studies of TRE focus on weight loss in young male mice, but the Salk scientists wanted to determine whether TRE confers additional benefits in other populations.
Their results showed that although age and gender affect the results of TRE, the feeding strategy offers multiple health benefits for young and old of both sexes, and indicated that TRE can be a valuable intervention. for type 2 diabetes, fatty liver and liver cancer. , and even infectious diseases such as COVID-19, in humans.
“For many clinical TRE interventions, the primary outcome is weight loss, but we have found that TRE is good not only for metabolic disease, but also for increased resilience against infectious disease and insulin resistance. “said Satchidananda Panda, professor at Salk’s Regulatory Laboratory of Biology and holder of the Rita and Richard Atkinson Chair.
Glucose intolerance is the first step on a slippery slope towards non-alcoholic fatty liver disease and liver cancer – one of the few cancers whose incidence and death rates have increased, rather than decreased, over the years. 25 to 30 years.
What’s more, more than 40% of Americans already have diabetes or prediabetes, with the American Diabetes Association predicting 1.5 million new cases each year.
These trends make finding a simple treatment for glucose intolerance a high priority.
Breaking the conventional mold of young male mice, the researchers gave a diet high in fat and sugar to male and female mice of two age groups (equivalent to 20- and 42-year-old humans), limiting the diet to nine hours a day.
The team performed tests to determine how age and gender affect TRE scores on a variety of health parameters: fatty liver disease; regulation of glucose; muscle mass, performance and endurance; and survival from sepsis, a potentially fatal response to infection.
They also took the rare step of adapting their lab conditions to the animals’ circadian clocks (mice sleep during the day and get up at night), often working with night vision goggles and specialized lighting.
By analyzing mouse tissues on TRE to verify their chemical composition and processes, the researchers found that regardless of age, gender, or weight loss profile, TRE provided strong protection against fatty liver disease, a disease that affects up to 100 million Americans and for which no drug has been approved.
“This was our first time studying female mice, and we weren’t sure what to expect,” said first author Amandine Chaix, former scientist at the Panda lab and now assistant professor at the University of Utah.
“We were surprised to find that although females on TRE were not protected against weight gain, they still had metabolic benefits, including lower fat livers and better controlled blood sugar,” added Chaix. .
Oral glucose tolerance tests in mice after 16 hours of fasting indicated that ERR was associated with a lower increase in blood sugar and a faster return to normal blood sugar in young and male males. middle age, with significant improvement in glucose tolerance in young and middle-aged females.
Likewise, middle-aged females and males on TRE were able to restore normal blood sugar levels more efficiently than control mice, which were provided with food at all times.
This finding indicated that TRE can be a user-friendly and inexpensive way to prevent or treat diabetes, and supports the results of the 2019 lab study of TRE for metabolic syndrome in humans.
The researchers also found that TRE can protect both men and women from death induced by sepsis – a particular danger in intensive care units, especially during the pandemic.
After administering a toxin that induced a sepsis-like condition in mice, the researchers monitored survival rates for 13 days and found that TRE protected both male and female mice from dying from sepsis.
TRE not only protected against fatty liver disease, diabetes, and death from sepsis; it even allowed male mice to preserve and add muscle mass and improve muscle performance (the effect was not valid for females).
This result is particularly significant for the elderly, for whom improving muscle performance can help protect against falls.
This startling discovery points to next steps and new questions for Panda’s lab: Does muscle mass increase because TRE helps muscles repair and regenerate better? What is the impact of TRE on metabolism and muscle regeneration?
“These are very exciting questions for us, and we look forward to exploring them in more detail,” said Panda.
The research was supported by the American Heart Association, the National Institute on Aging, the Glenn Center for Aging Research, and the Wu-Tsai Human Performance Alliance. (ANI)